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Statements about the underlying values and preferences as well as qualifying remarks accompanying each recommendation are its integral parts and serve to facilitate more accurate interpretation.

Brain parenchymal damage after haematopoietic stem cell transplantation for severe sickle cell disease.

Your condition will not improve any faster, and the risk of serious side effects may be increased.

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These changes were accompanied by significant reductions in the percentage of sickled cells observed after equilibration with gas mixtures containing 1 to 7 percent oxygen ( Figure 3 Effect of Hydroxyurea Therapy on the Percentage of Sickled Cells in Red-Cell Suspensions Incubated at Reduced Oxygen Tension.

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Capsaicin should be handled using a glove and applied to affected areas three or four times daily.

Hydroxyurea is used to treat skin cancer (melanoma), a cancer of the white blood cells called chronic myelocytic leukemia (CML), and metastatic cancer (cancer that has spread) of the ovaries.

Effect of Hydroxyurea Therapy on Resting Energy Expenditure in Children With Sickle Cell Disease.

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Transfusion Therapy in β Thalassemia and Sickle Cell Disease.

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However, since this complication is generally seen only after long-term treatment, careful follow-up of hydroxyurea-treated patients is mandatory.

Clinical and Laboratory Effects of Hydroxyurea in Children and Adolescents with Sickle Cell Anemia: A Portuguese Hospital Study.

This multi-center study was completed on 293 patients in an outpatient setting and examined VLU receiving either compression therapy alone compared with compression therapy and serial (up to 5) applications of the human skin equivalent, Apligraf.

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Athletes who possess the sickle-cell trait can play competitive sports but should be monitored by trainers if they participate in intense workouts, according to guidelines published by both the NCAA and the National Athletic Trainers Association.

Sickle cell anemia is a multisystem disease associated with episodes of acute illness and progressive organ damage.

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Outcomes were diverse and included blood markers as measures of treatment effect (e.

This occurs because the sickle shaped cells prevent blood flow out of these extremities.

Dasatinib (Sprycel): Indicated for the treatment of adult patients with chronic myeloid leukemia in chronic, accelerated, or myeloid or lymphoid blast phase who are resistant or intolerant to prior therapy including imatinib.

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Because these infections are uncommon, previous delays in diagnosis have resulted in death in some patients.

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PSK combined with chemotherapy significantly prolonged survival time compared with chemotherapy alone.

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We treated five patients with sickle cell disease with escalating doses of intravenous erythropoietin for eight weeks.

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With the emerging resistance to imatinib treatment after its launch alternative treatment was highly sought after.

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This review describes newly identified mechanisms for the effects of HU, including genetic regulation of fetal hemoglobin (HbF) as a disease modifier and the biologic effects of HU on blood vessels and gene regulation.

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Dactylitis, or painful swelling of the fingers and toes, is a common first symptom of sickle cell anemia in children and infants.

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On January 14, 1995, the study was stopped, and the clinical investigators in the 21 participating centers were notified of the study's results and the efficacy and safety of hydroxyurea therapy.

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Bone marrow transplantation is considered too risky for adults with sickle cell disease, because they cannot tolerate the chemotherapy regimen as well as children and they tend to have long-term organ damage as a result of the condition.

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